Type of Drug
A combination of drugs used to reduce the risk of duodenal (stomach intestinal) ulcer recurrence caused by infection with H. pylori.
How The Drug Works
Lansoprazole reduces gastric (stomach) acid secretion by blocking the final step of gastric acid production. Amoxicillin kills bacteria by preventing the production of the bacterial cell wall. Clarithromycin suppresses the formation of vital proteins by bacteria, slowing bacterial growth.
For the treatment of H. pylori infection and duodenal (stomach/intestina ulcers (active or 1-year history of a duodenal ulcer) to eradicate H. pylor and prevent ulcer recurrence.
Diarrhea: If diarrhea develops during lansoprazole/amoxicillin/clarithromycin use, pseudomembranous colitis must be considered. This inflammatory condition of the colon is due to overgrowth of bacteria that are not killed by lansoprazole/amoxicillin/clarithromycin. The primary cause is a toxin produced by a bacteria known as Clostridia difficile. Colitis symptoms may range in severity from mild to life-threatening. Mild cases usually respond by stopping the antibiotic. In more severe cases other antibiotics may need to be used.
Pregnancy: Adequate studies have not been done in pregnant women. Use only if clearly needed and potential benefits outweigh the possible hazards to the fetus.
Breastfeeding: Amoxicillin appears in breast milk. Because of the potential for serious adverse effects, decide whether to discontinue nursing or discontinue the drug. Consult your doctor.
Children: Safety and effectiveness in children have not been established
Tell your doctor or pharmacist if you are taking or if you are planning to take any over-the-counter or prescription medications or dietary supplements while taking this medicine. Doses of one or both drugs may need to be modified or a different drug may need to be prescribed. The following drugs and drug classes interact with this medicine.
Amoxicillin only Allopurinol (eg, Zyloprim)
Contraceptives, Oral (eg, Ortho-Novum, Ovral) Probenecid (Benemid)
Tetracyclines (eg, tetracycline HCI)
Clarithromycin only Anticoagulants, Oral (eg, warfarin)
Benzodiazepines (eg, alprazolam, diazepam, midazolam, triazolam)
Cyclosporine (eg, Neoral, Sandimmune)
Dihydroergotamine or ergotamine (eg, Ergomar)
Every drug is capable of producing side effects. Many patients experience no, or minor, side effects. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. Possible side effects include:
Digestive Tract: Diarrhea; taste changes; nausea; dark stools; sore tongue; mouth sores; tongue discoloration; dry mouth; thirst; indigestion; stomach pain or irritation; vomiting; rectal itching.
Urinary and Reproductive Tract: Vaginal inflammation; vaginal infection.
Nervous System: Headache; confusion; dizziness.
Other: Muscle pain; itching; rash; hives.
Guidelines for Use
Take exactly as prescribed.
Each medication packet contains enough medication for 2 doses.
Usual adult dose is 30 mg lansoprazole (1 pink and black capsule), 1 g amoxicillin (2 maroon and light pink capsules), and 500 mg clarithromycin (1 yellow tablet) taken together twice daily before eating (morning and evening) for 14 days. Swallow each pill whole.
Failure to complete full course of therapy may allow the infection to return.
If a dose is missed, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose in order to catch up unless advised to do so by your doctor. If more than 1 dose is missed, or if it is necessary to establish a new dosage I schedule, contact your doctor or pharmacist.
Discontinue therapy immediately and contact your doctor if any of the following occurs: Rash; hives; difficulty breathing; swelling of the eye-lids, face, tongue, or lips.
Notify your doctor if diarrhea develops while taking this medicine or shortly after completing therapy.
This product contains a penicillin. Tell your doctor if you have a penicillin allergy .
Decreased dosage or dosing intervals of clarithromycin may be necessary for patients with severe kidney impairment and will be determined by your doctor.
Store at controlled room temperature (59 0 to 86°F). Protect from light and moisture.